Inhibition of food-stimulated gastric acid secretion by cimetidine.
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چکیده
منابع مشابه
Inhibition of food-stimulated gastric acid secretion by cimetidine.
The effect of cimetidine, a new histamine H2-receptor antagonist, on gastric acid secretion stimulated by a homogenised meal was studied in six normal volunteers using an in vivo intragastric titration technique. The subjects were studied twice, no more than 48 h apart, receiving either cimetidine 200 mg or placebo in random order. Cimetidine administered either 32 men before (three subjects) o...
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In a double-blind, placebo controlled and randomised secretory study the effectiveness of pirenzepine, ranitidine, and their combination was compared intraindividually in eight healthy subjects receiving intravenous bolus injections. Pirenzepine (0.15 mg/kg) plus ranitidine (0.6 mg/kg) suppressed peptone-stimulated gastric acid secretion from 69 +/- 11 to 2 +/- 0.4 mmol H+/3 h; the mean percent...
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It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240 g) were deprived of food but not the water 24 h b...
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Histamine-stimulated gastric secretion in man is inhibited when the intraduodenal pH is reduced to 2 5 or less (Johnston and Duthie, 1964). The characteristics of the inhibition are these (Fig. 1); the onset is rapid, within two minutes; the degree depends on the potency of the stimulant and inhibitor, but is about 570 in normal subjects when the dose of histamine is 0-2 ,ug./kg./min. and the p...
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ژورنال
عنوان ژورنال: Gut
سال: 1976
ISSN: 0017-5749
DOI: 10.1136/gut.17.3.161